March 28th, 2023
Lyon — NETRIS Pharma, a clinical-stage private biopharmaceutical company developing a new class of drugs based on dependence receptor biology, today announced dosing of the first patients in a multicenter, prospective, single arm, proof-of-concept trial of the anti-netrin-1 antibody, NP137, in combination with mFOLFIRINOX in first line patients with locally advanced pancreatic ductal adenocarcinoma. Called Lap-NET1 (NCT05546853), the study will enroll 43 to 52 patients and consists of two parts: a safety lead-in phase, with 3-12 patients, and an expansion phase of 40 patients, where efficacy endpoints including best overall objective response rate (ORR) will be measured.
“The start of the Lap-NET1 trial is a new important clinical milestone for NETRIS Pharma, and our fourth clinical trial currently recruiting. Pancreatic cancer is very complex to treat. However, in close collaboration with US colleagues, we demonstrated that netrin-1 is a key regulator of pancreatic cancer progression. Our lead drug candidate NP137, that targets netrin-1, is effective in controlling disease progression in a variety of preclinical models, and when combined with chemotherapies, has been shown to alleviate the cancer’s resistance to these conventional treatments. There is thus a strong interest to investigate the potential of combining NP137 with mFOLFIRINOX, currently used as a first-line treatment for pancreatic cancers,”, said Patrick Mehlen, CEO of NETRIS Pharma.
LapNET-1 is an investigator initiated trial led by Gael Roth as Principal Investigator from Centre Hospitalier Universitaire Grenoble Alpes (CHUGA), with participation of 10 other clinical centers, part of the PRODIGE Group.
“Although pancreatic cancer patient care is improving, primarily given the earlier detection or tumors, and the benefit of mFOLFIRINOX as standard of care in Western Europe, this difficult to treat disease is on the rise with incidence prediction studies suggesting that it will eventually represent the 2nd leading cause of cancer-related death in Western countries,” said Gael Roth, clinical oncologist at CHUGA and Principal Investigator of LapNET-1. « I Look forward to lead this clinical trial, given the strong scientific rationale of combining NP137 with mFOLFIRINOX ».
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