Aims to combine NETRIS Pharma’s mAb with selected radioisotopes
September 20th, 2022
LYON, France — NETRIS Pharma SAS, a private clinical-stage biopharmaceutical company, announced today that it has entered into a scientific collaboration agreement with Orano and the Centre Léon Bérard (CLB) to develop novel Antibody Radio-Conjugates for the treatment of cancer. Initially, the parties intend to conduct a preclinical proof-of-concept efficacy study with new radio-conjugate targeting Netrin-1, combining Netris’ monoclonal antibody (mAb) NP137 with undisclosed radioelement from Orano.
“Based on strong preclinical evidence showing the potential of linking NP137, our proprietary mAb, with approved radioelements for both imaging and therapy purposes, this collaboration with Orano and CLB has the potential to develop novel radio-conjugate that provide significant clinical benefits to patients,” said Patrick Mehlen, Founder and Chief Executive Officer of NETRIS Pharma.
Both NETRIS Pharma and Orano have entered into this collaboration with Centre Léon Bérard based on the potential opportunities brought by novel radioisotope conjugates in oncology. Under the terms of the agreement, planned to be completed within one year, NETRIS Pharma, Orano and CLB will contribute their unique respective expertise in anti- netrin-1 biology and mode-of-action, radioisotope and nuclear based products, and preclinical and clinical oncology expertise to develop new compounds for clinical use.
“For Orano, it is a real opportunity to couple a new radioisotope with NP137developed by NETRIS Pharma thanks to the know-how of the Léon Bérard Comprehensive Cancer Center, in order to create a highly effective compound,” declared Guillaume Dureau, Orano’s Director of Research & Development and Innovation. “With this collaboration, we hope to lay the foundation of a long-term partnership driven by the significant complementary expertise of the three partners.”
“The vectorized radiotherapy practice of the Léon Bérard Comprehensive Cancer Center is among the most innovative ones in Europe,” said Jean-Yves Blay, General Director of CLB. “New technologies using original cargoes to deliver radioelement are key to provide more effective treatments to patients. With the collaboration leveraging our strong clinical practice, we look forward to the future developments of this project”.
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